Applications Vaccixcell

Non Anchorage Cell Culture

  1. Cell-Based Vaccine Manufacturing

    Vaccines are produced by cultivating viruses which are then used for immunization. Traditionally, these viruses are cultivated in egg-based methods but this method proves to be problematic. A new trend in vaccine production nowadays is to use cell-based virus culture. Cells are cultured in stirred tanks, whether by suspension or by adherence to micro carriers. One major advantage of using a cell-based culture is that there is no lead time involved as opposed to the egg-based method. Egg-based method rely on the supply of biosecure eggs from biosecure flocks. For cell-based culture, all that is needed is the proper cell line, media and equipment. Another advantage of cell-based culture is that it can easily scale up to industrial production scale.

    Another major advantage of cell-based vaccine manufacturing is the ease of integrating the upstream and downstream processing. Once the virus has been inoculated into the cells and have multiplied, downstream processing can begin in sequence in order to acquire the desired products.

    Esco VacciXcell being one of the leaders in the field of bioprocessing is able to supply you with an end-to-end solution for your vaccine manufacturing needs.

    To know more about Esco VacciXcell StriCradle bioreactor (Link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  2. Cosmetic

    Fermented food has been known to have health benefits for a long time and now it is being used in cosmetics. Fruits with properties which benefit the skin, such as vitamins, probiotics, beneficial enzymes, were once only available through oral routes but now with the introduction of fermentation technology to the cosmetic world, these benefits can be integrated into topic applications such as masks. Fermentation not only preserves these nutrients but also in essence make these nutrients easier to absorb by the skin due to the metabolic action that occurs during fermentation process, breaking down nutrients and other substances which would have been too difficult for the skin to absorb. A common application are beauty masks with fermented ingredients. These masks are said to have a milder but equally as effective ingredients compared to non-fermented counter parts.

    Esco VacciXcell’s stirred tank fermentation bioreactor is not only capable of producing quality fermented products but is able to ensure that these products are safe and free from unwanted microorganisms. Through sterilization-in-place technology and various pre-filters and filters, Esco VacciXcell’s StirCradle and StirCradle Pro makes fermentation a worry free process. StirCradle and StirCradle Pro are also capable of monitoring and controlling temperature and aeration, giving you full control of your process for your desired results.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  3. Organic Agriculture

    Organic farming is the alternative and more natural system of agriculture wherein synthetic chemicals are not used. Fertilizers used for organic farming consequently must come from natural organic sources. The problem with these sources is that they are not readily usable as fertilizers since they must reach a certain level of decomposition before they can be beneficial to the soil and the plants.

    Because of this, fermentation is introduced to organic agriculture since it hastens the decomposition of organic waste products. By doing so, organic fertilizers can be produced timely and easily. Esco VacciXcell’s stirred tank bioreactor provides you with a fully automated procedure with programmable steps for all parameters: agitation, temperature, pH control, DO control, airflow and pressure. Set it up, leave it and let Esco VacciXcell’s fermenter bioreactors do it for you. Now you can be sure that your products will come out just the way you want it even with the most minimal of efforts.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  4. Microorganisms for Special Purposes (Waste Water Treatment)

    Waste water treatment has been a persistent problem that the world consistently face. As the world becomes more industrialize, more and more of the world’s water supply become polluted, specially by heavy metal. Advances have been made in the area of water recycling and recovery and one of the more cost efficient method discovered is using special microorganisms which can do specific purposes, such as metal encapsulating microorganisms. Stirred tanks can be used for culturing these heavy metal resistant microorganisms which in turn could be used for waste water treatment from industrial zones. These microorganisms would absorb the heavy metals, especially cadmium, which could then be disposed of or recycled.

    Esco VacciXcell’s StirCradle stirred tank is capable of culturing any microorganisms and even have specially designed vessels for fungi culture, preventing them from being stagnant on a single part on the vessel. As the science of fermenter and cell culture becomes wider and more encompassing, having a fermenter bioreactor that can adapt to any microorganisms and/or cell line is essential to avoid future capital expenditures due to obsolescence. Not only is Esco VacciXcell’s StirCradle designed for all types of fermentation and culture, we at Esco VacciXcell are also able to integrate whatever necessary additional features you might need for special fermentation and culturing process.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

    To learn more about pre-formulated and customized media (link: http://www.vaccixcell.com/products-and-brands/culture-medium/#content)

     

  5. Production of Special Chemicals

    Special chemicals such as surfactants has been vital to food, pharmaceutical, petroleum, cosmetics and even water and soil related industries. They are either used as ingredients or as buffers to achieve desired results in these field. As the current trend is to shift from synthetic to biodegradable products, special chemicals are now also being produced by microorganisms, modified or otherwise. Biosurfactants, for example, can be produced through culturing of Bacillus Subtilis given the proper substrates.

    In order to properly culture and produce the desired end product, environment, media and substrates must be considered aside from the microorganisms used. Microorganisms that are grown properly in an appropriate bioreactor can grow and multiply more rapidly than those which are cultured in a poor environment. Esco VacciXcell can provide not only the proper equipment but also the optimal media for any microorganism. StirCradle and SitrCradle Pro are stirred tank bioreactors capable of culturing bacteria and microorganisms which are amiable to suspension culturing. Esco VacciXcell’s culture medium are serum free mediums which makes downstream processing that much easier.

    Esco VacciXcell is able to provide you with a one stop shop for all your suspension culturing needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

    To learn more about pre-formulated and customized media (link: http://www.vaccixcell.com/products-and-brands/culture-medium/#content)

     

  6. Aquaculture

  7. Aquaculture pertains to growing and harvesting aquatic organisms, whether freshwater or saltwater, such as fish and aquatic plants under controlled environmental conditions. This is an alternative to traditional fish catching which mostly rely on aquatic wildlife.

    Similar to agriculture, several advances has been discovered and made in the field of aquaculture, one of which is using the power of microorganisms to promote a better aquatic environment for whatever produce is being bred. One of the more famous microorganism being used for this purpose is the ever so popular probiotics. However, adding probiotics into an aquatic environment is easier said than done. By fermenting soy for example, will produce probiotics. However, by doing fermentation of such type, other microorganisms included in the soy would also grow and multiply. These microorganisms then can be a potential harm for the aquatic environment.

    By using a designated microorganism fermenter/bioreactor, specific microorganisms can be selected and grown in an in vitro environment. These microorganisms, such as lactobacillus, can then be cultured in a repeated manner to produce as many quantity as required without the risk of accidentally culturing unwanted microorganism at the same time. VacciXcell’s stirred tank bioreactor, StirCradle, can do all this and more. StirCradle provides a sterile environment for whatever microorganism is to be cultured while ensuring that all pertinent parameters are monitored and controlled to give the best yield possible. StirCradle also boasts of a wide variety of impellers which makes sure that proper oxygen transfer is achieved while culturing without subjecting the microorganisms to extremely low shear stress.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation and culturing needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  8. Energy Production

    Sugars are natural sources of energy for living cells. It is a vital ingredient in the production of adenosine triphosphate which then becomes the fuel of cells. In industries however, fossil fuels are the go to source of energy in order to provide power to a car or electricity to a city. As fossil fuels run low, more and more alternative ways of creating energy has been developed, one of this is using alcohol based substance to create renewable and sustainable energy source.

    By using fermentation, sugar sources are converted into alcohol. Yeast is a very good example of this, converting pyruvic acid into ethanol. Methods such as this can be used to create alternative fuel for renewable energy sources as ethanol is a well-recognized alternative fuel. The challenge then lies in the process of producing, extracting and purifying the alcohol.

    Esco VacciXcell’s stirred tank bioreactor and fermenter technology is not only capable of providing an ideal environment for yeast to grow and multiply but is also capable of continuously keeping equilibrium in the culture environment regardless of the acidity that the produced alcohol is contributing. On top of this, Esco VacciXcell’s StirCradle and StirCradle Pro bioreactors can easily be connected to any downstream process, making production a seamless and flawless process.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  9. Functional Food (Antrodia, Lactobacillus,ganodema, red yeast rice)

    Food has since been the primary source of nutrients for the human body. Since then, it has evolved into not just a necessity but a form of pleasure with all sorts of taste being invented, re-invented and developed every day. The big question then is this: how can healthy food be delicious at the same time? One solution to this is what is called as functional food.

    Functional food such as yoghurt, are food which supposedly have health benefits to the human body. One of the processes that create functional food is fermentation. Yoghurt is derived from fermentation of milk which adds healthy microorganisms to it such as probiotics.

    Esco VacciXcell is able to provide solution to any of your processes’ fermentation need while maintaining sterility and safety of the food being fermented. Esco VacciXcell’s stirred tank fermenters, SitrCradle and StirCradle Pro, can be sterilized before culture for both the equipment and the media. Sanitary sampling ports are provided in order to have a safe way of testing at any point in the process. Also, different working volumes are available, from 5L all the way to 1,000L, to cater to your fermentation production needs.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation and culturing needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)

     

  10. Suspended Cell Culture

    Suspended cell culturing is appropriate for nonadhesive cells or cells which have been modified such that they are amiable to suspension culture. Microorganisms such as bacteria are also naturally adaptable to suspension cell culture making this the ideal method in cultivating these microorganisms, The main advantage of suspension cell culturing vs adherent cell culturing is that it is not reliant on surface area for growth and yield but rather is reliant on the volume of media which provides easy scale up.

    Esco VacciXcell is able to provide you with a one stop shop for all your fermentation and culturing needs. From laboratory scale to production scale, Esco VacciXcell has all the necessary technology for you. Whether it be R&D or final production, Esco VacciXcell products are bound to be your best choices. To learn more about our stirred tank fermenters (link: http://www.vaccixcell.com/products-and-brands/fermenter-stirred-tank-bioreactor/#content)