Applications Vaccixcell

Pancreatic Cancer Vaccine

The pancreas is a glandular organ situated behind stomach in the abdominal cavity. It is responsible for production of some vital hormones such as insulin. It also aids in digestion by releasing pancreatic juice which contains enzymes that breakdown carbohydrate, proteins and lipids.

Being an important organ for the digestive and metabolic system, it is sad to know that by age 40, the chance of contracting pancreatic cancer severely increases. Pancreatic adenocarcinoma makes up more than 80% of all pancreatic cancers. Common symptoms of pancreatic cancer includes back and abdominal pain, yellowing of skin and digestive cues such as weight loss and loss of appetite. Symptoms are not very definitive which leads to most cancers being left undetected until it is in advance stages


Surgery is the first line of treatment for pancreatic cancer however it relies on one important thing: if the tumor and cancer cells can be encapsulated in the pancreas that will be removed. If the cancer cells has spread out of the pancreas, then surgical removal of the organ will be futile.

As with other forms of cancer, chemotherapy is used as a supplementary management procedure to surgical removal of the tumor. Radiotherapy also has the same role. Both of these treatments however has severe adverse effects on the patient.

Advances in pancreatic cancer treatment has been made in the past few years. A revolutionary therapeutic vaccine, CRS-207, uses bacteria within the vaccine to produce protein mesothelin, an antigen often expressed by solid tumors. In turn, this "programs" the immune system to hunt the tumors.


For bacterial culture, VacciXcell's stirred tank bioreactors are excellent bioprocessing companions. Click here to learn more:


CRS-207 - 10 promising therapeutic vaccines